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A Finnish research group has found a genetic cause for lactose
intolerance. Millions of people globally suffer from lactose
intolerance or the inability to break down sugar lactose.
Thanks to the gene find, the condition can be diagnosed by
a simple blood test instead of a complex set of exercises.
The most common cause of lactose intolerance is the limited
ability of the body to produce the lactase enzyme which breaks
down sugar lactose. A large part of the world's population
suffers from a sugar lactose absorption disorder. In the United
States, for example, it is estimated that 30-50 million people
suffer from this ailment. In Finland, one out of every six
people suffers from it.
It was already known that the lactase gene (LPH gene)itself
is not responsible for the body's inability to break down
sugar lactose. The Finnish researchers discovered a variation
in the DNA code, situated in another part of the same chromosome.
Nine Finnish families and 236 persons of other ethnic origin
participated in the research carried out by the Biomedicum
network. The results show that the DNA variation was present
in those suffering from intolerance, but not in the rest.
Exactly how the variation promotes the creation of intolerance
is still somewhat uncertain. Based on the research it is known
that a person must inherit the variant gene from both parents
in order to become lactose intolerant.


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www.biomedicum.fi
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